Will Vaping Set Off Hotel Smoke Alarms? Can Hotel Smoke Detectors Detect Vape Can Hotel Rooms Detect Vape Smoke Can You Vape in a Hotel Room? Read This Guide Do Hotels Know If You Vape? What Happens If They Find Out? UponArriving Your guests aren't the only ones checking in. So are their vape pens. With over 13 million regular vapers in the U.S. alone, unauthorized vaping is a major operational risk for hotels.